The study intends to draw attention to the need for regulatory guidelines and the potential of this product in the market and peoples' health. However, it needs regulatory guidelines to control the production and guarantee the product's efficacy and safety. This natural product has been developed to improve or promote physical and mental health. Legislative efforts about these products remain confusing and without global harmonization. Kombucha is an increasingly consumed product classified as a nutraceutical. Сonclusion : Ointment prepared from 20% scoby improved the healing of diabetic ulcers within 14 days. The expression of MMP1 decreased on the ten and fourteenth days when using 20% kombucha ointment compared to the control, placebo, and 10% kombucha ointment groups (p > 0.05).ĭiscussion : The histopatological finding indicated that both quantity and time duration of the treatment had significant effects on a degree of inflammation and angiogenesis. MMP1 levels increased on the second (p 0.05). Also 20% kombucha ointment led to an increase in vascular remodeling and penetration of fibroblasts. Results : 20% kombucha ointment let to inflammation and an angiogenesis decrease compared to those in the basic group and 10%-kombucha-ointment group. Microscopic features, inflammation and vasculature and fibroblast infiltration, as well as the matrix metalloproteinase 1(MMP1) were evaluated on days 2, 5, 10, 14 after wound healing. Then the rats in each group were divided to 4 sampling groups that were sampled on the second, fifth, tenth, and fourteenth days. The animals were randomly divided into 4 groups: the group that was treated with base ointment, the group that was treated with 10% kombucha ointment, the group that was treated with 20% kombucha ointment, and the group that received no ointment treatment. A 6 mm diameter ulcer was aseptically created on the back of forty-eight rats with streptozotocin-induced diabetes. Materials and methods : This study was conducted at research Lab, Department of Micobiology, Falavarjan of Branch Islamic Azad University, Isfahan, Iran from October 2019 to September 2020. Clinical and histopathological effects of the kombucha ointment on the healing of diabetic wounds were evaluated. Introduction : High blood glucose results in high levels of matrix metalloproteinases.

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